| Seed Line | Seed | Team |
| 1 | 1 | Purdue |
| 1 | 2 | Connecticut |
| 1 | 3 | Houston |
| 1 | 4 | Arizona |
| 2 | 5 | North Carolina |
| 2 | 6 | Tennessee |
| 2 | 7 | Marquette |
| 2 | 8 | Kansas |
| 3 | 9 | Alabama |
| 3 | 10 | Duke |
| 3 | 11 | Iowa St. ⬆️ |
| 3 | 12 | Baylor |
| 4 | 13 | Auburn |
| 4 | 14 | Creighton ⬇️ |
| 4 | 15 | San Diego St. |
| 4 | 16 | Wisconsin |
| 5 | 17 | Illinois |
| 5 | 18 | Dayton |
| 5 | 19 | Kentucky ⬆️ |
| 5 | 20 | Clemson |
| 6 | 21 | Florida |
| 6 | 22 | Texas Tech |
| 6 | 23 | BYU ⬇️ |
| 6 | 24 | Washington St. ⬆️ |
| 7 | 25 | Utah St. |
| 7 | 26 | South Carolina ⬆️ |
| 7 | 27 | Saint Mary’s |
| 7 | 28 | TCU ⬆️ |
| 8 | 29 | Michigan St. ⬇️⬇️ |
| 8 | 30 | Oklahoma ⬇️ |
| 8 | 31 | Mississippi St. ⬆️ |
| 8 | 32 | Colorado St. |
| 9 | 33 | Nebraska ⬆️⬆️ |
| 9 | 34 | Northwestern ⬆️ |
| 9 | 35 | Texas ⬇️ |
| 9 | 36 | Nevada ⬆️ |
| 10 | 37 | Boise St. |
| 10 | 38 | Wake Forest 🆕 |
| 10 | 39 | Florida Atlantic ⬇️ |
| 10 | 40 | Providence ⬆️ |
| 11 | 41 | Virginia ⬇️⬇️ |
| 11 | 42 | Seton Hall 🆕 |
| 11 | 43 | Gonzaga ⬇️ |
| 11 | 44 | New Mexico ⬇️⬇️ |
| 11 | 45 | Indiana St. 🆕 |
| 11 | 46 | Grand Canyon |
| 12 | 47 | Richmond |
| 12 | 48 | McNeese St. |
| 12 | 49 | Appalachian St. |
| 12 | 50 | South Florida ⬆️ |
| 13 | 51 | Samford ⬇️ |
| 13 | 52 | Cornell |
| 13 | 53 | UC Irvine |
| 13 | 54 | Akron |
| 14 | 55 | Vermont |
| 14 | 56 | Charleston |
| 14 | 57 | High Point |
| 14 | 58 | Oakland |
| 15 | 59 | Colgate |
| 15 | 60 | Eastern Washington |
| 15 | 61 | Sam Houston ⬆️ |
| 15 | 62 | Fairfield 🆕 |
| 16 | 63 | South Dakota St. |
| 16 | 64 | Eastern Kentucky |
| 16 | 65 | Norfolk St. |
| 16 | 66 | Merrimack |
| 16 | 67 | Little Rock 🆕 |
| 16 | 68 | Grambling |
| Last 4 Byes | Last 4 In | First 4 Out | Next 4 Out |
| Boise St. | Virginia ⬇️⬇️ | Colorado ⬆️ | Utah |
| Wake Forest ⬆️⬆️ | Seton Hall ⬆️ | Butler ⬇️ | St. John’s ⬆️ |
| Florida Atlantic ⬇️ | Gonzaga ⬇️ | Ole Miss ⬇️ | Drake 🆕 |
| Providence ⬆️ | New Mexico ⬇️⬇️ | Villanova | Texas A&M ⬇️ |
Also Considered: Oregon, Cincinnati, Pittsburgh, James Madison, Princeton, Iowa, Kansas St., Syracuse, Virginia Tech, Ohio State, Memphis
Shoutout to www.bracketmatrix.com for keeping track of all of the brackets over the years!